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Tirzepatide

Also known as: Mounjaro, Zepbound

Dual GLP-1/GIP agonist — the most effective weight loss peptide available

Method

injection

Level

beginner

Risk

high

Status

FDA Approved

Quick Summary

Dual GLP-1/GIP agonist — the most effective weight loss peptide available

Also called: Mounjaro, Zepbound

What is Tirzepatide?

Tirzepatide is a first-in-class dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonist developed by Eli Lilly. Clinical trials demonstrated unprecedented weight loss of up to 22.5% of body weight in the SURMOUNT-1 trial, surpassing semaglutide's efficacy. Approved as Mounjaro for type 2 diabetes and Zepbound for chronic weight management.

How It's Made

Tirzepatide is a synthetic 39-amino acid peptide that acts as a dual agonist at both GIP and GLP-1 receptors. It incorporates a C20 fatty diacid moiety that enables once-weekly dosing through albumin binding, similar to semaglutide's mechanism of extended half-life.

Potential Benefits

Up to 22.5% body weight reduction
Superior to semaglutide in head-to-head comparisons
Improved insulin sensitivity
Better GI tolerability than semaglutide
Cardiovascular benefits
Potential MASH/NAFLD treatment

Who Uses This?

Common goals and use cases for Tirzepatide:

Obesity managementType 2 diabetesMetabolic syndromeCardiovascular risk reduction

Where to Buy Tirzepatide

Affiliate links — use code for discount. Always consult a healthcare provider before use.

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